Side Effects

Though it is often said that GABA is free from any side effects, this theory has not been completely proven true. This is because some users have noted changes in their physical state which can be considered as side effects of GABA.

Possible GABA Side Effects

Some people using GABA have a tickly and itchy sensation on the face and around the neck right after the ingestion of GABA. Some others have noted a change in the way of breathing (either too fast or too slow) and a throbbing heart. But the side effects are not the same for everyone; one might experience an effect, while someone eels might not. These after effects last for a brief period and cause no harm.

It is better to follow a doctor’s advice before taking GABA, depending on your health condition. A person’s medical condition, which includes any severe disorders like diabetes, asthma, HBP, insomnia, anxiety, needs to be verified before using the GABA supplement.

As GABA is a form of amino acid it can be legally used as an aid, but the FDA (Food and Drug Administration) and the NIDA (National Institute on Drug Abuse) have stated that GCH and other compounds related to it can have adverse effects on human health and well being. These drugs have not been approved and are not safe to be used. They can cause seizures and other ill effects.

GABA is sedative and can cause drowsiness, it is better to ingest GABA at night, before retiring to bed. However, some distributors now combine GABA and B6, which allegedly negates the drowsiness and provides calm, relaxed, energetic feelings.

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{ 26 comments… read them below or add one }

Gina Snook February 20, 2012 at 5:20 pm

Is it safe to take with a anti-depressant.


Jeff Felderman February 25, 2012 at 1:09 pm

I have been taking anti-depppressants for a long time and GABA has been working fine with them. I am especially working on easing muscle tension and decreasing negative thoughts.


pearlkala March 24, 2012 at 5:42 am

i am on Zopiclone for insomnia.
I also have a few compressed nerves in the lumber area
and the doctor has prescribed Pregabalin.
Is it safe to combine Zopiclone and Pregabalin?


Donna September 15, 2012 at 1:42 pm

Pregabalin is not the same thing as GABA. It’s brand name is Lyrica, it is a prescription, and usually prescribed for Fibromyalgia/other uses are possible, like for Restless Legs Syndrome, but the jury is out on that one, so far. as far as using it in combination with other meds, you MUST ask your doctor or pharmacist.


Tb March 28, 2012 at 11:36 pm

Is GABA safe to take if you are hypothyroid or have no thyroid?


CR June 18, 2012 at 11:37 pm

I am taking the anti-depressant citalopram and am taking GABA at night, I am also taking stress B-complex during the day and plan on taking magnesium as well. The anti-depressant, GABA and stress B-complex work together very well in my case, so I would say it is safe to take with anti-depressants. But of course, you should double check with your doctor/notify them that you are taking it.


George June 25, 2012 at 8:09 pm

Can a person recovering from adrenal fatigue, use Gaba supplement?


Donna September 15, 2012 at 1:43 pm

you have to ask your doctor about that one. No one here can really answer that question for you.


Lawana September 18, 2012 at 9:15 am

Is GABA safe to use with Parkinson’s, Conjestive Heart Failure, & High Blood pressure?


vince September 19, 2012 at 5:53 pm

i HAVE BEEN INTRODUCED TO GABA by the use of neurontin. I take the pill for neuropthy of feet. When off the pill i have a bad reaction mentally. It is asking me for more. Do not to take more. Any sugestions on how to live with the drug. I must have neurontin to survive. the name of the drug is gabapentin. Thanks vince


Eric F November 12, 2012 at 4:58 pm

I have bi polar,insomnia ,anxiety with panic,and on occasion hear voices I mentioned GABA to my doctor she said as long as I don’t go over the recomened amout but is it safe I want a second opinion before I start. How long do I take it before bed.


blue May 24, 2013 at 9:39 pm

My brother has same symptoms as you, except for hearing voices & on my advice takes 500mg GABA & 500mg magnesium 30mins before sleep and it works very well. He says he hs not slept like this since childhood: 7h+ straight every night. Recommend you read the Mood Cure for more info.


BethD January 9, 2013 at 5:02 pm

I suffered with anxiety and bi-polar type 2 depression for a long time. I tried many of the antidepressants on the market, to no avail. I started taking Gaba 100 mg twice a day and worked my way up to 500mg an hour before bed. I was eventually able to get completely off of all medication and was quite stable on the Gaba 500 at bedtime. However; after several years of taking it, I began having allergic type symptoms. Itching all over, feelings of needle pricks all over when out in the sun and Chills. I stopped the Gaba and had withdrawl symptoms of depression. I am at this moment looking for another manufacturer that doesn’t include B-6 in their Gaba and start once again. Taking nothing , for me may be worse than the side effects.


Jadedfairy January 15, 2013 at 1:00 am

My mental health provider mentioned trying GABA, Im currently take medication for a small tumor on my pituitary glad, aswell as bipolar, anxiety, depression & methadone for server pain! I have read through all of the info on this page, the many many uses for GABA, Have to say I’m impressed that 1 natural vitamin can work so well in so many ways! I’M wondering, if it wld be safe fit me to take it as I take so many, medications that do help & unfortunately the side effect of some are drowsiness, but there are so many things that I’ve Read that GABA could help w/I’m wondering if it’s worth a try? To see if it would help w/out having to take more prescription drugs..? Maybe a DR’s advise would be advisable..TY all for you’re helpful info ..


Eric G March 8, 2013 at 7:56 pm

I have battled anxiety for many years and wanted to try Gaba so I started taking it once in a while. I noticed that I was getting a flushed feeling in my face with tingling around my lips, neck and eyes. A few time I couldn’t control my breathing and heart rate (which can make you feel panicky)… I took one a few days ago and had the same reaction to the point where I had to sit and calm down and focus on breathing slowly… I just took one an hour ago and already feel it hitting me. At least I know that it’s the Gaba causing it. I don’t think I need this to deal with anxiety and panic.


joan April 28, 2013 at 3:23 pm

Eric… the GABA may have niacin in it or something else that may cause your side effects.


Ann November 23, 2013 at 6:44 am

I found that when I took a full dose of GABA (750 mg,) I too, got those side effects. I open the capsule and sprinkle half of it on my tongue or if tablets, break them in half. I don’t have side effects with the smaller dose and it still works.


julie March 19, 2013 at 4:30 pm

I have insominia and I started taking Gabba last night so far so good; i slept and i have no side effects but of coursetime will tell i hope it works for me ive tried almost everything anyone have any suggestions maybe there is something i havent tried .. Im so desperate….


Julie s. April 7, 2013 at 10:01 am

Another julie with insomnia here! I tried at least a dozen different things to help with my insomnia and finally started taking .5 mg of xanax about 3 years ago. It has been perfect for me up until the last month or so. Now i only sleep 4-6 hours/night. Not wanting to increase my dose, i looked into other options (again) and GABA was suggested, which is how i got to this forum. I might give GABA a try, in addition to the xanax, but will talk to my doctor first. I have intense PACs (premature atrial contractions) so the heart-racing side effect concerns me. Good luck. Hope you continue to get some sleep.


Fred March 29, 2013 at 2:25 am

Gaba definitely helps me achive a more peaceful state of mind. I have had major anxiety issues my whole life (I’m 50) and I first started with the precursor “Lentra” which basically helps the body make Gaba. Unfortunately though it worked very well, it is also very costly. So now I take Gaba by itself. a lot less expensive than lentra but there is a rather disquieting side-effect I’ve noticed. I literally have trouble breathing for a minute or two. I find myself putting my head down as that seems to both alleviate the anxiety of not breathing well and improving air intake somehow.

Anyhow, if you can get past the shortness of breath periods then Gaba might be for you. Oh no, I sound like one of those commercials for pharmaceuticals that appears so rosey but then at the end says you can die as a side effect…haha


Stan August 5, 2013 at 10:28 pm

I was reducing my Seroquel and started having difficulty sleeping. I tried 5-HTP which converts to Seratonin and Melatonin when sleeping. Seroquel was also causing a lot of shortness of breath that I don’t have nearly as bad now.

“GABA CALM” (no niacin but has other ingredients) helped me reduce my klonapin because the klonapin withdrawls caused a physical anxiety in the mornings after awakening.

I’m weaning off the nasty prescription bipolar meds and leaning towards nutritional supplements.

Lithium carbonate can be switched to very low doses of lithium orotate also. Much less lethal.

So far, so good!!!

Best Wishes,
Stan P.


tammy August 21, 2013 at 7:28 pm

I take GABA due to I have MS, sometimes I feel I cannot sleep well at night due to legs feeling they are crawling around without me! I was wondering if anyone has noticed a stomach upset at all..


SUE September 16, 2013 at 11:36 pm

I take zyprexa and Haldol. I started taking GABA (it also had melatonin and 5-HTP). The first time I slept all night and almost all next day time. And I took only l/3 of the indicated dose (liquid form). I relaxes me but I don’t like to sleep more than 15 hrs a day!


Ron October 15, 2013 at 4:01 pm

I bought 500 mg GABA thinking the extra boost would help. Wrong. Way too drowsy. I now take about 150 mg before bed and I really feel like I am going into a coma I’m so relaxed. I do notice the positive side of GABA concerning the negative thoughts. I seem to be ready every morning not wondering what the negative side of life will hand me. It’s nice to smile a lot. Highly recommend in the 100 to 150 mg range


Ann November 23, 2013 at 6:48 am

I take 5htp, GABA and melatonin at night to sleep better. I must not be the only one that knows this works, because now I’ve seen two products that contain all three: Dream Water, which I saw at Pavilions and Sleep Please that I found at the 99 cent store.


Imergene December 14, 2013 at 2:23 am

I have ben taking 500 mg of gaba 2 times aday for 2 days.Get to sleep for a few hours wake up and can’tgo back to sleep.Also feel like my stomach knots up.Taking gaba because I needed something for nerves and to help me sleep better.Don’t lke taking drugs.What am I doing wrong?


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